US River Cruises from American Cruise Line

American Cruise Lines offers world-class, small ship cruises along the inland waterways and rivers of the United States. From the Mississippi River to New England and Alaska, their modern fleet of ships and paddlewheelers are the perfect way to see America.

Enjoy superb refinement on the newest ships built in the USA. Relax in finely appointed staterooms that are among the largest in the world while our attentive staff creates a personalized cruise experience where your every desire is met with care and precision.

Cruise itineraries include Mississippi River cruises, Pacific Northwest cruises, New England, Mid-Atlantic and Southeast US cruises from 7 to 14 nights.

Mississippi River Cruises aboard Queen of the Mississippi

The Queen of the Mississippi is the first new paddlewheel river boat built for the Mississippi River in nearly twenty years. It has revolutionized Mississippi River cruising by combining 21st century technology with the historic grandeur of cruises on past Mississippi River boats.

Discover the national history, lively culture and unforgettable beauty of the Mississippi River as we cruise from New Orleans, Memphis, St. Louis or St. Paul for an eight-day voyage along the iconic Mississippi River.

Maine Coast and Harbors Cruise

People have been drawn to the spectacular coast of Maine throughout history. As your small ship winds through scenic rivers, sparkling bays and historic harbors you’ll discover the undeniable magic found along Maine’s coast. From Boothbay to Bar Harbor, Camden to Castine, your journey brings you to charming ports famous for their shipbuilding, beautiful national parks and quaint historic districts. Stroll the charming village of Belfast, famous for its beautiful Greek revival architecture, awe at the granite mountains of Acadia National Park, and admire the classic schooners in Camden harbor. Come discover what makes Maine one of the most magical places in America.

Columbia and Snake Rivers Cruise

Cruise the Columbia and Snake Rivers along the epic route pioneered by Lewis and Clark more than 200 years ago. Join us aboard the paddlewheeler Queen of the West for an 8-day cruise through this rich tapestry of ever changing landscapes, thriving wildlife habitats and diverse wine country.

Queen of the West offers an intimate atmosphere with multiple lounges and cozy staterooms – each with a fantastic view of the river. Enjoy freshly prepared regional cuisine, local wine varietals and the personalized service of American Cruise Lines as we travel from Portland, OR to Clarkston, WA.

Lewis & Clark Theme Cruises

When Lewis & Clark began their famous expeditionary travels in the early 19th century, no one knew what they might find in western America. As they explored the land from St. Louis out towards the Pacific Ocean, the historical and cultural treasures helped secure the foundation of the Pacific Northwest as America began to expand.

Explore the Pacific Northwest region that Lewis & Clark once traveled on an exciting 8-day Columbia & Snake Rivers theme cruise. This exclusive Lewis & Clark theme cruise itinerary features a number of stops essential to the original journey, including Fort Clatsop, where the expeditionary team camped before heading back to St. Louis. During your cruise, the Queen of the West will also port in Astoria, Rainer and Pendleton, each bringing new life to the classic stories of Lewis & Clark.

Columbia River Wine Cruise

Indulge in a 7 night cruise through the heart of the Columbia River Valley’s extensive wine making heritage. This Columbia River cruise features onboard wine experts, wine samplings, and guided tours at several of the area’s finest vineyards. Your onboard wine expert will show you everything from the basics of wine tasting to advanced wine pairing and sensory evaluation.